反应详情

To a solution of 5-nitrocyclobutabenzen-1(2H)-one (900 mg, 5.52 mmol) in ethanol (25 mL) under a stream of nitrogen was added palladium on carbon (587 mg, 10%, 0.55 mmol). The mixture was placed under a hydrogen atmosphere (balloon) and stirred at ambient temperature for 16 hours. The reaction vessel was charged with nitrogen and the mixture filtered (ethanol wash). The filtrate was concentrated and purified by chromatography (silica gel, 20% EtOAc/hexanes) to provide the title compound. MS (DCI/NH3) m/z 151 (M+NH4)+.

1. additionThe reaction vessel was charged with nitrogen
2. filtrationthe mixture filtered
3. wash(ethanol wash)
4. concentrationThe filtrate was concentrated
5. custompurified by chromatography (silica gel, 20% EtOAc/hexanes)