Sulfuric Acid → 2,6-Dichloro-5-fluoronicotinamide

Participants

Reaction Conditions

Reaction Steps

A suspension of 25 g (130.90 mmol) of 2,6-dichloro-5-fluoro-3-cyanopyridine in conc. sulphuric acid (125 ml) was stirred for 1 h at 60-65° C. After cooling to RT, the flask contents were poured into ice water and extracted with ethyl acetate three times (100 ml each time). The combined organic phases were washed with water (100 ml) and then with saturated aqueous sodium hydrogen carbonate solution (100 ml), dried and concentrated in a rotary evaporator. The material obtained was dried under high vacuum.

Provenance & Evidence