Hydrazine hydrate (1:1) → HCID 178509230, compound

Participants

Reaction Steps

A suspension of 38.5 g (245.93 mmol) of 2-chloro-5-fluoronicotinonitrile in 1,2-ethanediol (380 ml) was prepared and then hydrazine hydrate (119.6 ml) was added. It was heated under reflux for 4 h, with stirring. On cooling, the product was precipitated. Water (380 ml) was added to the crystals and it was left to precipitate for 10 min at RT. Then the suspension was filtered with suction on a frit, and washed again with water (200 ml) and with cold (−10° C.) THF (200 ml). Drying over phosphorus pentoxide under high vacuum.

Provenance & Evidence