Water → N-[4-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)1-butynyl]phenyl]acetamide

HRID 53648Notes

Reaction equation

HRID 53648 reaction equation
[C:1]1([C:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][C:15]#[C:16][C:17]3[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=3)[CH2:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:24](Cl)(=[O:26])[CH3:25].O>>[C:1]1([C:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C:15]#[C:16][C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:26])[CH3:25])=[CH:19][CH:18]=3)[CH2:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 104250244-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)but-1-ynyl]aniline

Product 1

HCID 19960136N-[4-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)1-butynyl]phenyl]acetamide

Procedure

The title compound is prepared from 4-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl-1-butynyl]benzenamine (Example 21) and acetyl chloride, containing 0.1 mol of water; mp 172°-173.4° C.

Sources & evidence

ORD record
ord-e2f6c527f066440186dba1425429647b
Source dataset
uspto-grants-1997_04
Patent number
US05620988

Reaction notes

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