Ammonia → 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxamide

HRID 536480Notes

Reaction equation

HRID 536480 reaction equation
C([O:3][C:4]([C:6]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([F:15])[CH:13]=2)[N:8]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])[N:7]=1)=O)C.[NH3:24]>CO>[F:15][C:12]1[CH:13]=[C:14]2[C:6]([C:4]([NH2:24])=[O:3])=[N:7][N:8]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:9]2=[N:10][CH:11]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 56849011ethyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxylate

Product 1

HCID 568490095-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.00 g (3.152 mmol) of the compound obtained in example 8A was stirred in 10 ml of a 7N solution of ammonia in methanol at RT for three days. Then it was concentrated by vacuum evaporation. 908 mg (99% of theor.) of the title compound was obtained.

Workup

  1. concentrationThen it was concentrated by vacuum evaporation

Sources & evidence

ORD record
ord-deb44306dd234f52adabe93f4ad3f7c8
Source dataset
uspto-grants-2014_10
Patent number
US08859569B2

Reaction notes

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