反应详情

300 mg (1.15 mmol) of 1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide was dissolved with 2 ml tert.-butanol, 287 mg (1.38 mmol) of methyl-3,3-dicyano-2,2-dimethylpropanoate in 2 ml tert.-butanol and 181 mg (1.61 mmol) of potassium tert.-butylate was added and it was heated under reflux for 72 h. It was evaporated to dryness and the residue was mixed with water/isopropanol (v/v=3:1). The solid was filtered off and dried under high vacuum. 385 mg (80% of theor.) of the target compound was obtained.

1. additionwas added
2. temperatureit was heated
3. temperatureunder reflux for 72 h
4. customIt was evaporated to dryness
5. additionthe residue was mixed with water/isopropanol (v/v=3:1)
6. filtrationThe solid was filtered off
7. customdried under high vacuum
8. custom385 mg (80% of theor.) of the target compound was obtained