Ethanamine, 2,2,2-trifluoro- → HCID 71285655, compound

Participants

Reaction Conditions

Reaction Steps

150 mg (0.155 mmol, approx. 55% purity) of the compound obtained in example 21A was dissolved in 1-methyl-2-pyrrolidone (2.7 ml) in a reaction vessel suitable for a microwave and 0.675 ml 2,2,2-trifluoroethylamine was added. Then it was sealed with a corresponding septum and heated in the microwave at 150° C. for 21 h. After cooling, the reaction mixture was purified by preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient). 31 mg of the title compound was obtained (39% of theor.).

Provenance & Evidence