N-methyl-2-pyrrolidone → HCID 71285550, compound

Participants

Reaction Conditions

Reaction Steps

200 mg (0.206 mmol, approx. 55% purity) of the compound obtained in example 21A was dissolved in 1-methyl-2-pyrrolidone (4 ml) in a reaction vessel suitable for a microwave and 1 ml of aminomethylcyclopropane was added. Then it was sealed with a corresponding septum and it was heated in the microwave at 150° C. for 3 h. After cooling, the reaction mixture was purified by preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient). 64 mg of the title compound was obtained (65% of theor.).

Provenance & Evidence