反应详情

温度

150 °C

150 mg (0.186 mmol, approx. 66% purity) of the compound obtained in example 16A was dissolved in 1-methyl-2-pyrrolidone (3 ml) in a reaction vessel suitable for a microwave and 0.4 ml of 4,4,4-trifluorobutylamine was added. Then it was sealed with a corresponding septum and it was heated in the microwave at 150° C. for 3 h. After cooling, the reaction mixture was purified by preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient). 47 mg of the title compound was obtained (48% of theor.).

1. additionwas added
2. customThen it was sealed with a corresponding septum and it
3. temperatureAfter cooling
4. customthe reaction mixture was purified by preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient)