3,3,3-Trifluoropropylamine → HCID 71290256, compound

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere, 200 mg (purity 69%, 0.27 mmol) of 2-[8-(2-fluorobenzyl) imidazo[1,5-a]pyrimidin-6-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one (example 52A) was suspended in 3.2 ml of absolute NMP and 607 mg (5.37 mmol) of 3,3,3-trifluoropropan-1-amine was added. The mixture was stirred for 1.5 h at 150° C. in the microwave. The reaction solution was filtered and purified by preparative HPLC (eluent: acetonitrile/water with 0.1% hydrochloric acid, gradient 20:80→100:0). 41 mg (31% of theor.) of the target compound was obtained.

Provenance & Evidence