(1-Methyl-1H-pyrazol-5-yl)methanamine → HCID 71285373, compound

Participants

Reaction Steps

111.1 mg (1.0 mmol) of 1-(1-methyl-1H-pyrazol-5-yl)methanamine was put in a vial of a microwave reactor block and a solution of 51.4 mg (100 μmol) of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one (example 15A) in 0.6 ml of 1-methyl-2-pyrrolidinone was added. Then the reactor block was sealed and was irradiated for 6 h with microwaves, in order to reach and maintain a temperature of the mixture of 170° C. After cooling, it was purified by preparative LC-MS (method 6). The product-containing fractions were concentrated by evaporation by means of a centrifugal dryer under vacuum. The residue of the individual fractions was in each case dissolved in 0.6 ml DMSO and combined. Then the solvent was evaporated completely in the centrifugal dryer. 32.7 mg (61% of theor.) of the target product was obtained.

Provenance & Evidence