Cesium carbonate → HCID 71285673, compound

Participants

Reaction Steps

177 mg (0.54 mmol) of caesium carbonate and 114 mg (0.54 mmol) of 2,2,2-trifluoroethyl iodide were added to a suspension of 200 mg (0.5 mmol) of the compound from example 109 in DMF (1.97 ml) and it was stirred overnight at RT. Then it was heated in the microwave to 120° C. for 1 h. The reaction mixture was purified by preparative HPLC (Chromatorex C18, gradient of acetonitrile/0.01% aq. formic acid). Yield: 14.5 mg (6% of theor.).

Provenance & Evidence