2-Methyl-2-butene → HCID 58460141, compound

Participants

Reaction Steps

An amount of 345 mg (0.73 mmol) of the compound from Example 14A and also 0.58 ml (5.45 mmol) of 2-methyl-2-butene were dissolved in 3 ml of acetone and admixed at RT with a solution of 376 mg (2.73 mmol) of sodium dihydrogenphosphate-1-hydrate and 460 mg (4.07 mmol) of sodium chlorite in 9 ml of water. The mixture was stirred at this temperature for 16 hours thereafter and then diluted with 15 ml of water and with 15 ml of ethyl acetate. After the phases had been separated, the aqueous phase was further extracted with 15 ml of ethyl acetate, and the combined organic phases were washed with saturated sodium chloride solution and dried over magnesium sulphate. Following filtration, the solvent was concentrated and the residue was dried in a high vacuum. This gave 337 mg (104% of theory) of the target compound, which was reacted further without additional purification.

Provenance & Evidence