反应详情

温度

60 °C

An amount of 800 mg (3.39 mmol) of 5-(4-chlorophenyl)-4-cyclopropyl-2,4-dihydro-3H-1,2,4-triazol-3-one (preparation as per WO 2007/134862 Example 36A) and 1.66 g (5.09 mmol) of caesium carbonate were suspended in 10 ml of acetone and admixed with 1.14 g (4.41 mmol) of methyl-4-(bromomethyl)-3-methoxybenzenecarboxylate. The mixture was stirred at 60° C. for 2 h. The suspension was diluted with water. It was extracted with twice 15 ml of ethyl acetate. The combined organic phases were dried over sodium sulphate and freed from the solvent on a rotary evaporator. Purification by flash chromatography over silica gel with elution with cyclohexane/ethyl acetate (gradient 4:1→1:1) gave 910 mg (64% of theory) of the target compound.

1. extractionIt was extracted with twice 15 ml of ethyl acetate
2. dry with materialThe combined organic phases were dried over sodium sulphate
3. customfreed from the solvent on a rotary evaporator
4. customPurification by flash chromatography over silica gel
5. washwith elution with cyclohexane/ethyl acetate (gradient 4:1→1:1)
6. customgave 910 mg (64% of theory) of the target compound