反应详情

温度

80 °C

An amount of 830 mg (2.01 mmol) of the compound from Example 20A was dissolved in 10 ml of tetrahydrofuran/methanol (1:1) and admixed with 2 ml of a 2 N sodium hydroxide solution (4.01 mmol). The mixture was stirred at 80° C. for an hour. The reaction solution was diluted with 10 ml of water and extracted with twice 15 ml of ethyl acetate. The combined organic phases did not contain a product and were discarded. The aqueous product phase was acidified with 1 N hydrochloric acid and the resulting precipitate was isolated by filtration. The solid was dried in a high vacuum. Since the mother liquor still contained a large amount of product, it was concentrated completely on a rotary evaporator. This gave, all in all, 747 mg (93% of theory) of the target compound.

1. extractionextracted with twice 15 ml of ethyl acetate
2. customthe resulting precipitate was isolated by filtration
3. customThe solid was dried in a high vacuum
4. concentrationwas concentrated completely on a rotary evaporator