Methyl 3-{[3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}benzoate → 3-{[3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}benzoic acid

HRID 536548Notes

Reaction equation

HRID 536548 reaction equation
ClC1C=CC(C2N(CC(O)C(F)(F)F)C(=O)N(CC3C=CC(C(O)=O)=CC=3)N=2)=CC=1.[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([C:38]2[N:42]([CH2:43][CH:44]([OH:49])[C:45]([F:48])([F:47])[F:46])[C:41](=[O:50])[N:40]([CH2:51][C:52]3[CH:53]=[C:54]([CH:59]=[CH:60][CH:61]=3)[C:55]([O:57]C)=[O:56])[N:39]=2)=[CH:34][CH:33]=1>>[Cl:31][C:32]1[CH:33]=[CH:34][C:35]([C:38]2[N:42]([CH2:43][CH:44]([OH:49])[C:45]([F:47])([F:46])[F:48])[C:41](=[O:50])[N:40]([CH2:51][C:52]3[CH:53]=[C:54]([CH:59]=[CH:60][CH:61]=3)[C:55]([OH:57])=[O:56])[N:39]=2)=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 58460127Methyl 3-{[3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}benzoateHCID 584601374-{[3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}benzoic acid

Product 1

HCID 584601303-{[3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}benzoic acid

Procedure

In the same way as for the compound from Example 28A, 265 mg (0.58 mmol) of the compound from Example 25A were reacted. This gave 250 mg (97% of theory) of the target compound.

Sources & evidence

ORD record
ord-f2bec4f82e354756bbac638f69bb724d
Source dataset
uspto-grants-2014_10
Patent number
US08859601B2

Reaction notes

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