Tert-Butylamine → HCID 46238691, compound

Participants

Reaction Steps

An amount of 50 mg (0.113 mmol) of the compound from Example 15A was introduced in 1 ml of DMF and admixed with 18 mg (0.136 mmol) of 1-hydroxy-1H-benzotriazole hydrate and with 28 mg (0.147 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride. After 10 minutes of stirring at RT, 2-methylpropan-2-amine (13.1 μl, 0.124 mmol) was added and the mixture was stirred further at room temperature overnight. Subsequently the reaction solution was diluted with methanol and purified by preparative HPLC [Method 5]. This gave 13 mg (24% of theory) of the target compound.

Provenance & Evidence