3-Pentanol → HCID 86685693, compound

HRID 536569Notes

Reaction equation

HRID 536569 reaction equation
C[O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:10]=[C:9]([CH3:11])[N:8]([CH2:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[OH:20])[N:7]=1.ClC[CH:24]([CH2:27][CH3:28])[CH2:25][CH3:26].CCC(O)CC>>[Cl:19][C:17]1[CH:16]=[CH:15][C:14]([O:20][CH:24]([CH2:27][CH3:28])[CH2:25][CH3:26])=[C:13]([CH:18]=1)[CH2:12][N:8]1[C:9]([CH3:11])=[CH:10][C:6]([CH2:5][CH2:4][C:3]([OH:2])=[O:21])=[N:7]1

Participants

4

Reactant 3

HCID 114283-PentanolHCID 107585Pentane, 3-(chloromethyl)-HCID 66634127HCID 66634127, compound

Product 1

HCID 86685693HCID 86685693, compound

Procedure

The title compound was prepared following the methods described in example 1 and example 2 starting from (example 2 step 5) 3-[1-(5-Chloro-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-3-yl]-propionic acid methyl ester replacing the method in example 2 step 6 with Mitsunobu method and 3-chloromethylpentane with 3-pentanol.

Sources & evidence

ORD record
ord-fd4135b22d5c45529590310fe7deece1
Source dataset
uspto-grants-2014_10
Patent number
US08859606B2

Reaction notes

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