反应详情

To a solution of (2-benzyloxy-5-bromo-phenyl)-methanol (4.36 g, 14.87 mmol) in DCM (200 ml) cooled with ice-bath under N2 atmosphere a 1M solution of PBr3 in DCM (14.87 ml, 14.87 mmol) was added. The mixture was stirred at that temperature for 15 min and then at RT overnight. The reaction was quenched with sat. NaHCO3 solution. The organic layer was separated, washed with brine, dried (MgSO4) and evaporated to dryness.

1. additionwas added
2. customat RT
3. customovernight
4. customThe reaction was quenched with sat. NaHCO3 solution
5. customThe organic layer was separated
6. washwashed with brine
7. dry with materialdried (MgSO4)
8. customevaporated to dryness