HCID 86671497, compound → HCID 67255935, compound

Participants

Reaction Steps

To a solution of (E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate (1 g, 3.4 mmol) in EtOH (20 mL) was added 10% Pd/C (w/w, 400 mg), and the mixture was stirred at room temperature under 1 atm of H2 overnight. The reaction mixture was filtered, and concentrated to give ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)propanoate (Scheme III, 15, X1=4-cyano-2-methylphenyl) (0.9 g, yield 90%) as gray oil. 1H NMR (CD3OD 400 MHz): δ 7.69 (s, 1H), 7.60 (dd, J=8 Hz, J=1.2 Hz, 1H), 7.34 (d, J=8 Hz, 1H), 7.26-7.23 (m, 2H), 4.05 (q, J=7.2 Hz, 2H), 2.67 (t, J=7.6 Hz, 2H), 2.45 (t, J=7.6 Hz, 2H), 2.19 (s, 3H), 1.19 (t, J=7.2 Hz, 3H).

Provenance & Evidence