HCID 14343212, compound → HCID 12637757, compound

HRID 536631Notes

Reaction equation

HRID 536631 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1>[Pd].CO>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1

Participants

4

Reactant 1

HCID 14343212HCID 14343212, compound

Product 1

HCID 12637757HCID 12637757, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-methyl-2-phenylethynyl-pyridine (18.2 g) and 10% palladium on carbon (2.0 g) in methanol (300 mL) is stirred under hydrogen atmosphere (50 psi) at ambient temperature until the triple bond is completely reduced (20 h). The mixture is filtered and the solvent is removed under reduced pressure.

Workup

  1. custom(20 h)
  2. filtrationThe mixture is filtered
  3. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-0d31274ee888454e9ace677326bfe6ae
Source dataset
uspto-grants-2014_10
Patent number
US08859580B2

Reaction notes

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