Hydrochloric Acid → HCID 67346013, compound

Participants

Reaction Steps

Aqueous 4 M NaOH solution (1 mL) is added to a solution of (2R,6R,11S)-3-(3H-benzoimidazole-5-carbonyl)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine-8-carboxylic acid ethyl ester (0.60 g) in ethanol (3 mL). The resulting solution is stirred at ambient temperature for 3 h. Then, the solution is slightly acidified (pH ca. 5) using 1 M hydrochloric acid and the resulting solution is extracted with ethyl acetate. The combined organic extracts are washed with brine and dried (MgSO4). The solvent is evaporated under reduced pressure to give the product as a white solid.

Provenance & Evidence