Dimethylamine → HCID 67343604, compound

Participants

Reaction Steps

2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (90 mg) is added to a solution of (2R,6R,11S)-3-(3H-benzoimidazole-5-carbonyl)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine-8-carboxylic acid benzoic acid (0.10 g) and ethyldiisopropylamin (53 μL) in dimethylformamide (2 mL). The resulting solution is stirred at ambient temperature for 20 min before dimethylamine (40% in H2O, 60 μL) is added. The solution is stirred overnight. The mixture is concentrated under reduced pressure and the residue is purified by HPLC on reversed phase (H2O/MeCN/NH3) to give the product as a solid.

Provenance & Evidence