Ammonia → HCID 67345133, compound

Participants

Reaction Steps

Triethylamine (38 μL) and acetic anhydride (26 μL) are added to a suspension of (9-aminomethyl-6,11,11-trimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-(3H-benzoimidazol-5-yl)-methanone (0.10 g) in acetonitrile (2 mL). The resulting mixture is stirred at ambient temperature for 1 h. Then, methanol (1 mL) and concentrated aqueous ammonia solution (0.5 mL) are added and the resulting solution is stirred for another 30 min. The solution is concentrated under reduced pressure and the residue is purified by HPLC on reversed phase (water/MeCN) to give the title compound as a white foam-like solid.

Provenance & Evidence