Ammonium Chloride → HCID 178461476, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of sodium azide (105 mg), NH4Cl (87 mg), and (2R,6R,11S)-3-(3H-benzoimidazole-5-carbonyl)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine-8-carbonitrile (0.30 g) in dimethylformamide (3 mL) is stirred at 100° C. overnight. Then, another portion of NaN3 (50 mg) and NH4Cl (40 mg) is added and the mixture is stirred at 110° C. for additional 14 h. After cooling to ambient temperature, the mixture is diluted with water and MeCN and purified by HPLC on reversed phase (MeCN/H2O/NH3).

Provenance & Evidence