HCID 67343592, compound → HCID 67345361, compound

HRID 536697Notes

Reaction equation

HRID 536697 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:12]3[CH2:19][CH2:18][C@:17]4([CH3:22])[C@H:20]([CH3:21])[C@H:13]3[CH2:14][C:15]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([N+:29]([O-])=O)[C:16]=34)=[O:11])=[CH:9][C:4]=2[NH:3][CH:2]=1>[Pd].CO>[NH2:29][C:23]1[C:16]2[C@@:17]3([CH3:22])[C@H:20]([CH3:21])[C@H:13]([N:12]([C:10]([C:8]4[CH:7]=[CH:6][C:5]5[N:1]=[CH:2][NH:3][C:4]=5[CH:9]=4)=[O:11])[CH2:19][CH2:18]3)[CH2:14][C:15]=2[CH:26]=[CH:25][C:24]=1[O:27][CH3:28]

Participants

4

Reactant 1

HCID 67343592HCID 67343592, compound

Product 1

HCID 67345361HCID 67345361, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 10% palladium on carbon (1.0 g) and (3H-benzoimidazol-5-yl)-[(2R,6R,11S)-8-methoxy-6,11-dimethyl-7-nitro-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl]-methanone (1.50 g) in methanol (20 mL) is shaken under hydrogen atmosphere at room temperature for 1 d. Then, the mixture is filtered and the filtrate is concentrated under reduced pressure to give the title compound as a foam-like solid.

Workup

  1. filtrationThen, the mixture is filtered
  2. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-8cee25365b1348b4985b97f7064c026d
Source dataset
uspto-grants-2014_10
Patent number
US08859580B2

Reaction notes

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