Triethylamine → HCID 66643231, compound

Participants

Reaction Steps

The product from Example 22D (2.6 g, 6 mmol) in CH2Cl2 (10 mL) and MeOH (10 mL) was treated with 4-methylbenzenesulfonic acid monohydrate (570 mg, 3 mmol). The mixture was stirred at rt for 1 hr. The mixture was neutralized with excess Et3N. The solvent was removed and the residue was purified by column chromatography using an Analogix® Intelliflash280™ (SiO2, 0-50% MeOH in ethyl acetate) to afford 580 mg (73%) of the title compound. 1H NMR (400 MHz, CDCl3) δ ppm 1.85 (t, J=6.14 Hz, 1H) 1.95-2.03 (m, 2H) 3.35 (s, 3H) 3.56-3.65 (m, 1H) 3.71-3.78 (m, 1H) 3.82 (dd, J=8.29, 4.30 Hz, 1H) 3.85-3.93 (m, 2H) 3.95-4.02 (m, 1H).

Provenance & Evidence