HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178441318, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Fluoro-5-(trifluoromethyl)benzoic acid | HCID 688292 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | (r)-5-Tert-butyl-3-((tetrahydrofuran-2-yl)methyl)oxazol-2(3h)-imine | HCID 66643286 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 178441318 | HCID 178441318 | — |
Reaction Steps
A mixture of Example 32B (2 g, 8.92 mmol), 1H-benzo[d][1,2,3]triazol-1-ol hydrate (1.37 g, 8.92 mmol), N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride (1.71 g, 8.92 mmol), 2-fluoro-5-(trifluoromethyl)benzoic acid (1.86 g, 8.92 mmol), and triethylamine (1.86 mL, 13.37 mmol) in 30 mL of THF was heated at 80° C. for 12 hr. The mixture was cooled to room temperature, diluted with EtOAc, washed with NaHCO3, dried over MgSO4 and concentrated. The residue was purified by flash chromatography on SiO2 (Hexanes:EtOAc, 0 to 50%) to give the title compound. MS (ESI) m/z 415 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859596B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-192f3783984f403bba69a2fbd50b88a3 |
| Source note | uspto-grants-2014_10 |