HCID 178456106, compound → HCID 178456107, compound

Participants

Reaction Steps

A suspension of Example 107 (40 mg, 0.081 mmol) and 10% Pd/C (20 mg) was stirred under an atmosphere of hydrogen (balloon) at room temperature for 2 hours. The mixture was filtered through Celite, and the filtrate was concentrated. The residue was purified by column chromatography using an Analogix® Intelliflash280™ (SiO2, 50% hexanes/EtOAc to 100% EtOAc to 9:1:0.1 EtOAc:MeOH:Et3N) to afford 27 mg (67%) of the title compound. 1H NMR (500 MHz, chloroform-d) δ ppm 1.00 (t, J=7.32 Hz, 3H) 1.42 (s, 9H) 1.60 (s, 3H) 1.65-1.80 (m, 2H) 1.81-1.91 (m, 1H) 1.97-2.08 (m, 1H) 3.66-3.81 (m, 2H) 3.85-3.92 (m, 3H) 3.87-3.97 (m, 1H) 4.17 (s, 1H) 4.31 (d, J=5.49 Hz, 1H) 4.39 (d, J=7.93 Hz, 1H) 4.55 (d, J=14.34 Hz, 1H) 6.62 (s, 1H) 6.95-7.16 (m, 2H) 7.51 (s, 1H) 8.09 (s, 1H); MS (DCI/NH3) m/z 498 (M+H)+.

Provenance & Evidence