2,4-Difluorophenyl isocyanate → HCID 44514205, compound

HRID 536797Notes

Reaction equation

HRID 536797 reaction equation
[N:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=3)[N:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[N:34]=[C:35]=[O:36]>>[F:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[NH:34][C:35]([NH:23][C:22]1[CH:24]=[CH:25][C:19]([C:9]2[N:8]=[C:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=2)=[CH:20][CH:21]=1)=[O:36]

Participants

3

Reactant 2

HCID 5932582,4-Difluorophenyl isocyanateHCID 453790874-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline

Product 1

HCID 44514205HCID 44514205, compound

Procedure

Starting from 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (0.105 g 0.30 mmoles) and 2,4-difluorophenyl isocyanate (71 mg, 0.45 mmoles) the title compound was isolated as a white solid. Yield; 40 mg (27%); (M+H)=498.6

Sources & evidence

ORD record
ord-e30589a52c1e4e728542435af50972b4
Source dataset
uspto-grants-2014_10
Patent number
US08859542B2

Reaction notes

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