Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 536862Generated: October 29, 2026

Trifluoroacetic acid → HCID 44546614, compound

https://huagongshe.com/reaction/536862

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantGlycine methyl ester hydrochlorideHCID 122755—
ReactantHCID 44548798HCID 44548798—
CatalystTriethylamineHCID 8471—
ProductHCID 44546614HCID 44546614—

Reaction Steps

Starting from 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-oxopiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea.TFA (50 mg) and glycine methyl ester hydrochloride (20 mg) and triethylamine (10 drops) and following the procedure as outlined in example 118 the title compound was isolated as its di-TFA salt after HPLC purification; MS (ES+) 574.8 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08859542B2
Source datasetuspto-grants-2014_10
ORD IDord-6d583b4a431b4e0196d5dee80a028f32
Source noteuspto-grants-2014_10