HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 58994978, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-(4-Nitrophenyl)piperidine-4-carbonitrile | HCID 57416099 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58994978 | HCID 58994978 | — |
Reaction Steps
A solution of 4-(4-nitro-phenyl)-piperidine-4-carbonitrile (as prepared in the previous step) in CH2Cl2 is treated with CH3COCl and DIEA. The mixture is washed with water, and the organic layer is dried (MgSO4) and concentrated in vacuo. The residue is purified by silica gel chromatography with the appropriate solvent to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859602B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-81221a7f76364e1091b2342ecd4e7187 |
| Source note | uspto-grants-2014_10 |