HCID 58994937, compound → HCID 58995028, compound

HRID 536967Notes

Reaction equation

HRID 536967 reaction equation
[CH3:1][O:2][C:3]([C:5]1([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[C:13]([N:18]3[CH2:23][CH2:22][CH:21]([CH3:24])[CH2:20][CH2:19]3)[CH:12]=2)[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=[O:4].[K+].[C:26]([C:28]1[N:29]=[C:30]([C:41]([O-])=[O:42])[N:31]([CH2:33][O:34][CH2:35][CH2:36][Si:37]([CH3:40])([CH3:39])[CH3:38])[CH:32]=1)#[N:27]>>[CH3:1][O:2][C:3]([C:5]1([C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:41]([C:30]3[N:31]([CH2:33][O:34][CH2:35][CH2:36][Si:37]([CH3:40])([CH3:39])[CH3:38])[CH:32]=[C:28]([C:26]#[N:27])[N:29]=3)=[O:42])=[C:13]([N:18]3[CH2:23][CH2:22][CH:21]([CH3:24])[CH2:20][CH2:19]3)[CH:12]=2)[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 58994937HCID 58994937, compoundHCID 67188357potassium 4-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

Product 1

HCID 58995028HCID 58995028, compound

Procedure

The title compound is prepared by the procedure of Example 16, step (e) using 4-[4-amino-3-(4-methyl-piperidin-1-yl)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (as prepared in the previous step) and potassium 4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylate (as prepared in Example 1, step (d)).

Sources & evidence

ORD record
ord-494c7b36c3b849a39faa417f8f1cd1e6
Source dataset
uspto-grants-2014_10
Patent number
US08859602B2

Reaction notes

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