HCID 58995014, compound → HCID 178424475, compound

HRID 536979Notes

Reaction equation

HRID 536979 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[NH:12][CH:13]=[C:14]([C:16]#[N:17])[N:15]=2)=[O:10])=[C:4]([C:18]2[CH2:23][CH2:22][C:21]([CH3:25])([CH3:24])[CH2:20][CH:19]=2)[CH:3]=1.[CH3:26][C:27]1([CH3:41])[CH2:32][C:31](=[O:33])[CH2:30][C:29]([CH3:35])([CH3:34])[N:28]1[CH2:36][C:37]([F:40])([F:39])[F:38]>>[CH3:24][C:21]1([CH3:25])[CH2:22][CH2:23][C:18]([C:4]2[CH:3]=[C:2]([C:31]3([OH:33])[CH2:30][C:29]([CH3:35])([CH3:34])[N:28]([CH2:36][C:37]([F:38])([F:39])[F:40])[C:27]([CH3:41])([CH3:26])[CH2:32]3)[CH:7]=[CH:6][C:5]=2[NH:8][C:9]([C:11]2[NH:12][CH:13]=[C:14]([C:16]#[N:17])[N:15]=2)=[O:10])=[CH:19][CH2:20]1

Participants

3

Reactant 2

HCID 58995014HCID 58995014, compoundHCID 1784244434-Cyano-1H-imidazole-2-carboxylic acid [4-bromo-2-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-amide

Product 1

HCID 178424475HCID 178424475, compound

Procedure

The title compound was prepared as described in Example 1, step (h) using 4-cyano-1H-imidazole-2-carboxylic acid [4-bromo-2-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-amide (as prepared in Example 1, step (g) and 2,2,6,6-tetramethyl-1-(2,2,2-trifluoro-ethyl)-piperidin-4-one (as prepared above). 1H-NMR (CD3OD; 400 MHz): δ 8.22 (d, 1H, J=8.4 Hz), 7.98 (s, 1H), 7.43 (dd, 1H, J=8.4, 2.0 Hz), 7.33 (d, 1H, J=2.0 Hz), 5.73 (br s, 1H), 4.18 (m, 2H), 2.28-2.36 (m, 4H), 2.08 (m, 4H), 1.73 (s, 6H), 1.58 (m, 2H), 1.42 (m, 6H), 1.08 (s, 6H). Mass spectrum (ESI, m/z): Calcd. for C30H38F3N5O2, 558.3 (M+H). found 558.0.

Sources & evidence

ORD record
ord-5e4c012e6127448b818e1a84b01ffa49
Source dataset
uspto-grants-2014_10
Patent number
US08859602B2

Reaction notes

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