HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 537062Generated: October 30, 2026
N-bromobutanimide → Ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoate
https://huagongshe.com/reaction/537062
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-3-furoate | HCID 66748598 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoate | HCID 66748591 | 77.9% |
Reaction Steps
To a solution of ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-3-furoate (20.0 g, 69.9 mmol) in DMF (90 mL) was added NBS (29.6 g, 168.1 mmol). The reaction mixture was allowed to stir at 80° C. overnight and then concentrated. The residue was washed with EtOH and filtered to give ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoate (20 g, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08859768B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-7f6fd8cc03f944ee8a3915adc15f1eda |
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| Source note | uspto-grants-2014_10 |
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