2'-(tert-Butyl)-4',6'-dihydrospiro[piperidine-4,5'-pyrazolo[3,4-c]pyridin]-7'(2'H)-one hydrochloride → 2'-tert-butyl-1-(1-(4-methoxybenzylamino)isoquinoline-7-carbonyl)-4',6'-dihydrospiro[piperidine-4,5'-pyrazolo[3,4-c]pyridin]-7'(2'H)-one

HRID 537196Notes

Reaction equation

HRID 537196 reaction equation
Cl.[C:2]([N:6]1[CH:14]=[C:13]2[C:8]([C:9](=[O:20])[NH:10][C:11]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:12]2)=[N:7]1)([CH3:5])([CH3:4])[CH3:3].[CH3:21][O:22][C:23]1[CH:43]=[CH:42][C:26]([CH2:27][NH:28][C:29]2[C:38]3[C:33](=[CH:34][CH:35]=[C:36]([C:39](O)=[O:40])[CH:37]=3)[CH:32]=[CH:31][N:30]=2)=[CH:25][CH:24]=1>>[C:2]([N:6]1[CH:14]=[C:13]2[C:8]([C:9](=[O:20])[NH:10][C:11]3([CH2:19][CH2:18][N:17]([C:39]([C:36]4[CH:37]=[C:38]5[C:33]([CH:32]=[CH:31][N:30]=[C:29]5[NH:28][CH2:27][C:26]5[CH:25]=[CH:24][C:23]([O:22][CH3:21])=[CH:43][CH:42]=5)=[CH:34][CH:35]=4)=[O:40])[CH2:16][CH2:15]3)[CH2:12]2)=[N:7]1)([CH3:5])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 674913562'-(tert-Butyl)-4',6'-dihydrospiro[piperidine-4,5'-pyrazolo[3,4-c]pyridin]-7'(2'H)-one hydrochlorideHCID 674916931-(4-Methoxybenzylamino)isoquinoline-7-carboxylic acid2×

Product 1

HCID 674915152'-tert-butyl-1-(1-(4-methoxybenzylamino)isoquinoline-7-carbonyl)-4',6'-dihydrospiro[piperidine-4,5'-pyrazolo[3,4-c]pyridin]-7'(2'H)-one

Procedure

The title compound was prepared by a method analogous to that described in Example 3, using 2′-tert-butyl-4′,6′-dihydrospiro[piperidine-4,6-pyrazolo[3,4-c]pyridin]-7′(2′H)-one hydrochloride salt (Intermediate 4) and 1-(4-methoxybenzylamino)isoquinoline-7-carboxylic acid (Intermediate 27). +ESI (M+H) 553.5.

Sources & evidence

ORD record
ord-91dafdd240c04e7e86250f6dfbd7d532
Source dataset
uspto-grants-2014_10
Patent number
US08859773B2

Reaction notes

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