HRID537196

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)n1cc2c(n1)C(=O)NC1(CCNCC1)C2.Cl

HCID67491356

未命名化合物

HCID67491693

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc(CNc2nccc3ccc(C(=O)N4CCC5(CC4)Cc4cn(C(C)(C)C)nc4C(=O)N5)cc23)cc1

HCID67491515

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by a method analogous to that described in Example 3, using 2′-tert-butyl-4′,6′-dihydrospiro[piperidine-4,6-pyrazolo[3,4-c]pyridin]-7′(2′H)-one hydrochloride salt (Intermediate 4) and 1-(4-methoxybenzylamino)isoquinoline-7-carboxylic acid (Intermediate 27). +ESI (M+H) 553.5.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-91dafdd240c04e7e86250f6dfbd7d532
来源数据集: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08859773B2
来源说明: uspto-grants-2014_10

反应 SMILES

Cl.[C:2]([N:6]1[CH:14]=[C:13]2[C:8]([C:9](=[O:20])[NH:10][C:11]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:12]2)=[N:7]1)([CH3:5])([CH3:4])[CH3:3].[CH3:21][O:22][C:23]1[CH:43]=[CH:42][C:26]([CH2:27][NH:28][C:29]2[C:38]3[C:33](=[CH:34][CH:35]=[C:36]([C:39](O)=[O:40])[CH:37]=3)[CH:32]=[CH:31][N:30]=2)=[CH:25][CH:24]=1>>[C:2]([N:6]1[CH:14]=[C:13]2[C:8]([C:9](=[O:20])[NH:10][C:11]3([CH2:19][CH2:18][N:17]([C:39]([C:36]4[CH:37]=[C:38]5[C:33]([CH:32]=[CH:31][N:30]=[C:29]5[NH:28][CH2:27][C:26]5[CH:25]=[CH:24][C:23]([O:22][CH3:21])=[CH:43][CH:42]=5)=[CH:34][CH:35]=4)=[O:40])[CH2:16][CH2:15]3)[CH2:12]2)=[N:7]1)([CH3:5])([CH3:3])[CH3:4]