HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-benzyloxyphenyl)-4-fluoropiperidine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (Diethylamino)sulfur trifluoride | HCID 123472 | — |
| Reactant | Tert-butyl 4-(3-benzyloxyphenyl)-4-hydroxypiperidine-1-carboxylate | HCID 67462234 | — |
| Product | 4-(3-benzyloxyphenyl)-4-fluoropiperidine Hydrochloride | HCID 67460771 | — |
Reaction Steps
This material was prepared from the reaction of tert-butyl 4-(3-benzyloxyphenyl)-4-hydroxypiperidine-1-carboxylate with diethylaminosulfur trifluoride followed by direct deprotection of the crude product with methanolic hydrogen chloride as described in Step 2 of Example 1 in 75% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859777B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-afd5661bd27447df80a41d6f60107128 |
| Source note | uspto-grants-2014_10 |