HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-benzyloxyphenyl)-4-fluoro-3-methyl-1-(2-phenoxyethyl)piperidine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzene, (2-bromoethoxy)- | HCID 68526 | — |
| Reactant | 4-(3-Benzyloxyphenyl)-4-fluoro-3-methylpiperidine hydrochloride | HCID 67463151 | — |
| Product | 4-(3-benzyloxyphenyl)-4-fluoro-3-methyl-1-(2-phenoxyethyl)piperidine Hydrochloride | HCID 67464269 | — |
Reaction Steps
This material was prepared by the alkylation of 4-(3-benzyloxyphenyl)-4-fluoro-3-methylpiperidine hydrochloride with 1-bromo-2-phenoxyethane and subsequent salt formation with methanolic hydrogen chloride as described in Step 3 of Example 1 in 67% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859777B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-f9a8a09088ee4fa383f28c860bb24456 |
| Source note | uspto-grants-2014_10 |