HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Methyl 3-[4-(3-Benzyloxyphenyl)-4-fluoro-3-methylpiperidin-1-yl]-2,2-dibenzylpropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Reactant | Methyl 3-[4-(3-Benzyloxyphenyl)-4-fluoro-3-methylpiperidin-1-yl]propionate | HCID 67464042 | — |
| Product | Methyl 3-[4-(3-Benzyloxyphenyl)-4-fluoro-3-methylpiperidin-1-yl]-2,2-dibenzylpropionate | HCID 67461666 | — |
Reaction Steps
This compound was prepared from methyl 3-[4-(3-benzyloxyphenyl)-4-fluoro-3-methylpiperidin-1-yl]propionate and 2.5 equivalents of both lithium hexamethyldisilazide and benzyl bromide as described in Step 2 of Example 4 with the exception that THF was used as the reaction solvent as opposed to toluene. The desired compound was obtained in 42% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859777B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-0a7be5818ade4f289e12873d74668795 |
| Source note | uspto-grants-2014_10 |