1,4-Dioxane hydrochloride → HCID 67110944, compound

HRID 537352Notes

Reaction equation

HRID 537352 reaction equation
[ClH:1].O1CCOCC1.[C:8]([C:10]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]1)#[N:9]>>[ClH:1].[C:8]([C:10]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)#[N:9]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68160870HCID 68160870, compound

Product 1

HCID 67110944HCID 67110944, compoundYield 99%

Procedure

4 M HCl/dioxane (905 μL, 3.62 mmol) was added to neat tert-butyl 4-cyano-4-(2-(3-ethoxy-3-oxopropyl)phenyl)piperidine-1-carboxylate at 23° C. and was stirred for 2 h. The solution was concentrated to yield ethyl 3-(2-(4-cyanopiperidin-4-yl)phenyl)propanoate hydrochloride (22, 230 mg, 99% yield over 2 steps).

Workup

  1. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-c3cfbb1a38134c4bac2016a9bc1a304f
Source dataset
uspto-grants-2014_10
Patent number
US08859776B2

Reaction notes

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