1,4-Dioxane hydrochloride → Ethyl 3-(2-(piperidin-4-yl)phenyl)propanoate hydrochloride

Participants

Reaction Steps

4 M HCl/dioxane (2.2 mL, 8.97 mmol) was added to neat tert-butyl 4-(2-(3-methoxy-3-oxopropyl)phenyl)piperidine-1-carboxylate at 23° C. and was stirred overnight. The reaction mixture was concentrated to yield methyl 3-(2-(piperidin-4-yl)phenyl)propanoate hydrochloride (24, 250 mg, 98% yield). LC/MS RT (5 min method)=1.14 min. Mass observed: 248.16 (M+H).

Provenance & Evidence