HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 537356Generated: October 30, 2026
Methanesulfonamide → HCID 67110988, compound
https://huagongshe.com/reaction/537356
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonamide | HCID 72879 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-(1,1-Dimethylethyl) 4-[2-(2-carboxyethyl)phenyl]-1-piperidinecarboxylate | HCID 49760674 | — |
| Reactant | HCID 86669375 | HCID 86669375 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofurane dichloromethane | HCID 21919333 | — |
| Product | HCID 67110988 | HCID 67110988 | — |
Reaction Steps
Acid 3-(2-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)propanoic acid obtained in step 1 of representative example 8 (40 mg, 0.12 mmol) and methane sulfonamide (17 mg, 0.18 mmol) were dissolved in THF/CH2Cl2 (0.5 mL/1.0 mL). DMAP (22 mg, 0.18 mmol) and EDC.HCl (35 mg, 0.18 mmol) were added and the reaction was stirred at 23° C. overnight. Water was added to the reaction mixture and was extracted with EtOAc (2×10 mL). The organic layers were dried over Na2SO4 and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08859776B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-e60b1d47e28049a98c71488005f58077 |
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| Source note | uspto-grants-2014_10 |
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