Sodium Hydroxide → HCID 87272897, compound

Participants

Reaction Conditions

Reaction Steps

To ethyl 5-(4-phenyl-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)pentanoate in ethanol was added 2.0 M NaOH aqueous solution and the mixture was stirred at 70° C. for 1 h. Then the solvent was removed in vacuo. The residue was redissolved in water, acidified with 6N HCl to PH ˜4, then extracted with EtOAc (2×30 ml), dried (MgSO4), concentrated, purified on Gilson, treated with 4.0 M HCl in dioxane (2-3 drops), lyophilized, to give 5-(4-phenyl-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)pentanoic acid A81 as white solid.

Provenance & Evidence