HCID 86669383, compound → HCID 52914453, compound

Participants

Reaction Steps

In an analogous procedure to representative example 65 step 2, ethyl 4-(2-(1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenylsulfonamido)butanoate was saponified to provide A58 as a white solid after lyophilization from water/acetonitrile: 1H NMR (300 MHz, CDCl3 8.80 (d, J=4.4 Hz, 1H), 8.07 (d, J=7.8 Hz, 1H), 7.98-7.84 (m, 1H), 7.60-7.30 (m, 4H), 6.99 (d, J=7.8 Hz, 1H), 6.72-6.50 (m, 1H), 5.61-5.30 (m, 4H), 3.90-3.67 (m, 1H), 3.43-0.70 (m, 25H).

Provenance & Evidence