HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzenesulfonyl chloride → 2-chloro-N-{1-[(4-methylpiperidin-1-yl)carbonyl]-3-phenylpropyl}benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzenesulfonyl chloride | HCID 76187 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 66997562 | HCID 66997562 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-chloro-N-{1-[(4-methylpiperidin-1-yl)carbonyl]-3-phenylpropyl}benzenesulfonamide | HCID 58504869 | — |
Reaction Steps
A mixture of 29 mg (0.11 mmol) of 1-(4-methylpiperidin-1-yl)-1-oxo-4-phenylbutan-2-amine, 2-chlorobenzenesulfonyl chloride, and 0.19 mL (0.11 mmol) of iPr2NEt in 4 mL of CH2Cl2 is stirred for 16 h, concentrated, and purified by preparative HPLC to provide Example 1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859814B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-bdcee84947504fc8a58484f8b899e073 |
| Source note | uspto-grants-2014_10 |