Sulfuryl chloride → N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide

HRID 537395Notes

Reaction equation

HRID 537395 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH:11]([NH2:21])[C:12]([N:14]1[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]1)=[O:13].[S:22](Cl)(Cl)(=[O:24])=[O:23]>>[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH:11]([NH:21][S:22]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)(=[O:24])=[O:23])[C:12]([N:14]1[CH2:15][CH2:16][CH:17]([CH3:20])[CH2:18][CH2:19]1)=[O:13]

Participants

3

Reactant 2

HCID 24648Sulfuryl chlorideHCID 669975284-(2-Chlorophenyl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-amine hydrochloride

Product 1

HCID 58504875N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide

Procedure

Examples 6-38 are prepared from 4-(2-chlorophenyl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-amine hydrochloride and the appropriate sulfonyl chloride in a manner similar to the synthesis of Example 5.

Sources & evidence

ORD record
ord-eda28fae969045fdbb2d66cbd89b6024
Source dataset
uspto-grants-2014_10
Patent number
US08859814B2

Reaction notes

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