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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 537396Generated: October 26, 2026

N-Methylbenzylamine → tert-Butyl{(1R)-1-[benzyl(methyl)carbamoyl]-3-phenylpropyl}carbamate

https://huagongshe.com/reaction/537396

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-MethylbenzylamineHCID 7669—
ReactantBoc-D-homophenylalanineHCID 2755954—
ReactantTert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamateHCID 131731949—
Producttert-Butyl{(1R)-1-[benzyl(methyl)carbamoyl]-3-phenylpropyl}carbamateHCID 91008624—

Reaction Steps

tert-Butyl{(1R)-1-[benzyl(methyl)carbamoyl]-3-phenylpropyl}carbamate is prepared from Boc-(D)-homophenylalanine and N-methylbenzylamine in the same manner that tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate is synthesized.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08859814B2
Source datasetuspto-grants-2014_10
ORD IDord-035cdb81f8654fce985440edd280cf6c
Source noteuspto-grants-2014_10