HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-indole-4-sulfonyl chloride → N-{1-[(4-methylpiperidin-1-yl)carbonyl]-3-pyridin-4-ylpropyl}-1H-indole-4-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-indole-4-sulfonyl chloride | HCID 55280799 | — |
| Reactant | Tert-butyl{1-[(4-methylpiperidin-1-yl)carbonyl]-3-pyridin-4-ylpropyl}carbamate | HCID 131731951 | — |
| Product | N-{1-[(4-methylpiperidin-1-yl)carbonyl]-3-pyridin-4-ylpropyl}-1H-indole-4-sulfonamide | HCID 58504862 | — |
Reaction Steps
Example 53 is prepared from 70 mg (0.19 mmol) of tert-butyl{1-[(4-methylpiperidin-1-yl)carbonyl]-3-pyridin-4-ylpropyl}carbamate and indole-4-sulfonyl chloride in the same manner as Example 49 (51 mg, 60% yield). ESI MS Calc. 440.2; Found: 441.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859814B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-c0769db479fc473bbeba26b63aa56292 |
| Source note | uspto-grants-2014_10 |