1H-indole-4-sulfonyl chloride → N-{3-(2-bromophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}-1H-indole-4-sulfonamide

HRID 537405Notes

Reaction equation

HRID 537405 reaction equation
C(OC(=O)[NH:7][CH:8]([C:18]([N:20]1[CH2:25][CH2:24][CH:23]([CH3:26])[CH2:22][CH2:21]1)=[O:19])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[Br:17])(C)(C)C.[NH:28]1[C:36]2[CH:35]=[CH:34][CH:33]=[C:32]([S:37](Cl)(=[O:39])=[O:38])[C:31]=2[CH:30]=[CH:29]1>>[Br:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH2:10][CH2:9][CH:8]([NH:7][S:37]([C:32]1[C:31]2[CH:30]=[CH:29][NH:28][C:36]=2[CH:35]=[CH:34][CH:33]=1)(=[O:38])=[O:39])[C:18]([N:20]1[CH2:21][CH2:22][CH:23]([CH3:26])[CH2:24][CH2:25]1)=[O:19]

Participants

3

Reactant 2

HCID 552807991H-indole-4-sulfonyl chlorideHCID 91378583Tert-butyl{3-(2-bromophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

Product 1

HCID 58504854N-{3-(2-bromophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}-1H-indole-4-sulfonamide

Procedure

Example 67 is subsequently prepared from tert-butyl{3-(2-bromophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate and indole-4-sulfonyl chloride in the same manner that Example 5 is synthesized. ESI MS Calc. 517.1; Found: 518.2 (M+H)+.

Workup

  1. customis synthesized

Sources & evidence

ORD record
ord-c3f8c64bb051402d90c119cbdb44b87d
Source dataset
uspto-grants-2014_10
Patent number
US08859814B2

Reaction notes

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