HCID 66998209, compound → HCID 58504849, compound

HRID 537414Notes

Reaction equation

HRID 537414 reaction equation
C(OC(=O)[NH:7][CH:8]([C:20]([N:22]1[CH2:27][CH2:26][CH:25]([CH3:28])[CH2:24][CH2:23]1)=[O:21])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17](=[O:19])[NH2:18])[CH:12]=1)(C)(C)C.C(OC([N:37]1[C:45]2[CH:44]=[CH:43][CH:42]=[C:41]([S:46]([OH:48])=[O:47])[C:40]=2[CH:39]=[CH:38]1)=O)(C)(C)C.[Li]>>[NH:37]1[C:45]2[C:40](=[C:41]([S:46]([NH:7][CH:8]([C:20]([N:22]3[CH2:23][CH2:24][CH:25]([CH3:28])[CH2:26][CH2:27]3)=[O:21])[CH2:9][CH2:10][C:11]3[CH:12]=[C:13]([CH:14]=[CH:15][CH:16]=3)[C:17]([NH2:18])=[O:19])(=[O:48])=[O:47])[CH:42]=[CH:43][CH:44]=2)[CH:39]=[CH:38]1

Participants

3

Reactant 2

HCID 66998209HCID 66998209, compoundHCID 131731953HCID 131731953, compound

Product 1

HCID 58504849HCID 58504849, compound

Procedure

Example 85 is prepared from [3-(3-carbamoyl-phenyl)-1-(4-methyl-piperidine-1-carbonyl)-propyl]-carbamic acid tert-butyl ester and lithum 1-(tert-butoxycarbonyl)-1H-indole-4-sulfinic acid in the same manner as Example 71. ESI MS Calc. 482.2; Found. 483.7 (M+H)+.

Sources & evidence

ORD record
ord-0f7108b1d92747e3bb1fa47c4b00c893
Source dataset
uspto-grants-2014_10
Patent number
US08859814B2

Reaction notes

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